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Tuning Rhodium enhanced metalloprobes for intracellular use

Thesis Defense

Graduate and Postdoctoral Studies

By: Matthew Minus
Doctoral Candidate
When: Thursday, June 1, 2017
3:00 PM - 4:00 PM
Where: BioScience Research Collaborative
Abstract: Transition-metal complexes have a significant history as intracellular medicinal agents. Modern chemical biology increasingly turns to transition-metal complexes as inhibitors, imaging agents, biological probes, and catalysts. When metal complexes must function inside of cells, it is important to understand the cellular uptake and stability of the complex, especially when designing coordination complexes to interact with a defined biological target. Rh(II) coordination has enhanced the potency of inhibitors for several different target-proteins. However, the effects of Rh(II) enhancement were not previously demonstrated in cells. This thesis will present the development of novel Rh(II)-enhanced STAT3 inhibitors that exhibit increased intracellular potency and discuss the optimization of these metalloinhibitors for intracellular efficacy.